2 Information about dabrafenib with trametinib
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Anticipated marketing |
Dabrafenib (Tafinlar, Novartis Pharmaceuticals) with trametinib (Mekinist, Novartis Pharmaceuticals) is indicated for 'the adjuvant treatment of adult patients with stage III melanoma with a BRAF V600 mutation, following complete resection'. |
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Dosage in the marketing authorisation |
For dabrafenib, the recommended dose is 150 mg taken orally, twice daily. For trametinib, the recommended dose is 2 mg taken orally, once daily. |
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Price |
The list price for 28 capsules of dabrafenib 75 mg is £1,400 and for 30 tablets of trametinib 2 mg is £4,800 (company submission). The company has a commercial arrangement for each drug. This makes dabrafenib with trametinib available to the NHS with a discount. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount. |