Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma

Encorafenib (Braftovi, Pierre Fabre) in combination with binimetinib (Mektovi, Pierre Fabre) is indicated for 'the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation'.

For encorafenib, the recommended dose is 450 mg (6×75‑mg capsules) taken orally, once daily. For binimetinib, the recommended dose is 45 mg (3×15‑mg tablets) taken orally, twice daily, 12 hours apart.

The list price for 42 capsules of encorafenib 75 mg is £1,400 and for 84 tablets of binimetinib 15 mg is £2,240 (company submission). The company has a commercial arrangement for each drug. This makes encorafenib with binimetinib available to the NHS with a discount. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.