Voclosporin with mycophenolate mofetil for treating lupus nephritis

2.1 Voclosporin (Lupkynis, Otsuka) is indicated 'in combination with mycophenolate mofetil for the treatment of adult patients with active class 3, 4 or 5 (including mixed class 3/5 and 4/5) lupus nephritis'.

2.2 The dosage schedule is available in the summary of product characteristics for voclosporin.

2.3 Voclosporin costs £1,000 per 180‑pack of 7.9 mg soft capsules (excluding VAT; company submission). Voclosporin costs £12,167 for 12 months of treatment. The list price of mycophenolate mofetil is £6.23 per 50‑pack of 500 mg tablets (excluding VAT; BNF online accessed March 2023).

2.4 The company has a commercial arrangement. This makes voclosporin available to the NHS with a discount. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.