2 Information about axicabtagene ciloleucel

Marketing authorisation indication

2.1

Axicabtagene ciloleucel (Yescarta, Kite) is indicated for 'the treatment of adult patients with diffuse large B-cell lymphoma (DLBCL) and high-grade B‑cell lymphoma (HGBL) that relapses within 12 months from completion of, or is refractory to, first-line chemoimmunotherapy'.

Dosage in the marketing authorisation

Price

2.3

The list price of axicabtagene ciloleucel for a single infusion including shipping, engineering and generation of chimeric antigen receptor (CAR) T‑cells is £280,451 (company submission).

2.4

The company has a commercial arrangement. This makes axicabtagene ciloleucel available to the NHS with a discount. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.