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Showing 5716 to 5730 of 7707 results

  1. Second-line maintenance therapy in children and young people (under 16):- Is maintenance therapy more effective with a paediatric low dose of ICS plus a leukotriene receptor antagonist (LTRA) or with a paediatric low dose of ICS plus a long-acting beta2 agonist (LABA) in the treatment of asthma in children and young people (under 16) who have uncontrolled asthma on a paediatric low dose of ICS alone?

    Recommendation ID NG80/7 Question Second-line maintenance therapy in children and young people (under 16):- Is maintenance therapy more

    Research recommendation
    Published
    18 October 2018

  2. SEM Scanner 200, with visual skin assessment, shows promise for preventing pressure ulcers. However, there is not enough good-quality evidence to support the case for routine adoption in the NHS. A randomised controlled trial is recommended to address uncertainties about the clinical benefits of using the scanner compared with standard risk assessment. This should assess: using the scanner plus visual skin assessment compared with visual skin assessment alone for identifying pressure ulcer risk whether changes in clinical decision making from using the scanner reduce pressure ulcer incidence the clinical benefits and resource impact of using the scanner in different care settings the clinical benefits for different skin tones how well the scanner works across populations with a range of comorbidities patient-related outcome measures.

    Recommendation ID MTG51/1 Question SEM Scanner 200, with visual skin assessment, shows promise for preventing pressure ulcers. However

    Research recommendation
    Published
    26 October 2020

  3. Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG tissue transglutaminase (tTG), IgG endomysial antibodies (EMA) and IgG deamidated gliadin peptide (DGP) tests in detecting coeliac disease in people with IgA deficiency?

    Recommendation ID NG20/1 Question Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG

    Research recommendation
    Published
    13 October 2015

  4. Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and specificity of IgA EMA and IgA DGP tests in detecting coeliac disease inpeople who test negative for IgA tTG?

    Recommendation ID NG20/2 Question Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and

    Research recommendation
    Published
    13 October 2015

  5. Service delivery models:- Which models of service delivery are effective and cost-effective for older people with social care needs and multiple long-term conditions?

    Recommendation ID NG22/2 Question Service delivery models:- Which models of service delivery are effective and cost-effective for older

    Research recommendation
    Published
    11 December 2015

  6. Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study should be carried out to assess the incidence of suspected and proven neutropenic sepsis in patients having anticancer treatment.

    Recommendation ID CG151/1 Question Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study

    Research recommendation
    Published
    9 June 2015

  7. Research is needed to quantify the health outcome benefits associated with imaging improvements with the EOS system. Examples of such benefits might include reduced back pain or reduced postural difficulties in people with scoliosis, or longer lasting and less painful joint replacements. Although research into the use of the EOS system is appropriate for all the indications included in the scope, the research most likely to be useful is for planning hip and knee replacement, including patient selection, device selection, and surgical approach. Joint replacement operations are more common than the other indications and the EOS system is thought to be most likely to provide benefit to these patients.

    Recommendation ID DG1/1 Question Research is needed to quantify the health outcome benefits associated with imaging improvements with the

    Research recommendation
    Published
    9 June 2015

  8. Research is recommended to address uncertainties about the claimed patient and system benefits of the ReCell Spray-On Skin system. Clinical outcomes should include time to 95% healing, length of hospital stay, cosmetic appearance of the scar and function of the burned area, compared with standard care.

    Recommendation ID MTG21/1 Question Research is recommended to address uncertainties about the claimed patient and system benefits of the

    Research recommendation
    Published
    9 June 2015

  9. Research is recommended in the UK clinical setting to compare the BRAHMS copeptin assay in combination with cardiac troponin testing against sequential cardiac troponin testing for ruling out myocardial infarction.

    Recommendation ID MTG4/1 Question Research is recommended in the UK clinical setting to compare the BRAHMS copeptin assay in combination

    Research recommendation
    Published
    9 June 2015

  10. Research is recommended to address uncertainties about the claimed patient and system benefits of using Parafricta Bootees and Undergarments.

    Recommendation ID MTG20/1 Question Research is recommended to address uncertainties about the claimed patient and system benefits of using

    Research recommendation
    Published
    10 August 2021

  11. Research is recommended to address uncertainties in the potential benefits to patients and the NHS of using VibraTip. Research is needed into the diagnostic accuracy of VibraTip compared with the 10 g monofilament and calibrated tuning fork in the diagnosis of peripheral neuropathy in people with diabetes. This research should also address the assessment of vibration perception compared with touch sensation in this clinical context.

    Recommendation ID MTG22/1 Question Research is recommended to address uncertainties in the potential benefits to patients and the NHS of

    Research recommendation
    Published
    9 June 2015

  12. Research on second-line treatments for transitional cell carcinoma of the urothelial tract is needed. It noted that the vinflunine studies were the only studies in patients with transitional cell carcinoma of the urothelial tract whose disease had progressed after platinum-based chemotherapy. It was noted that there is a lack of evidence for the relative effectiveness of treatment options at this stage in the pathway of care. It is recommended that studies be undertaken to investigate the relative safety and efficacy of second-line treatments for transitional cell carcinoma of the urothelial tract, particularly randomised controlled trials.

    Recommendation ID TA272/1 Question Research on second-line treatments for transitional cell carcinoma of the urothelial tract is needed

    Research recommendation
    Published
    9 June 2015

  13. Research on the safety and efficacy of superior capsular augmentation for massive rotator cuff tears should address patient selection, type of graft and technique used,long-term outcomes including shoulder function, and patient-reported outcome measures.

    Recommendation ID IPG619/1 Question Research on the safety and efficacy of superior capsular augmentation for massive rotator cuff tears

    Research recommendation
    Published
    19 December 2018

  14. Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil at the higher dose used in the Chronic Lymphocytic Leukaemia Trial 4 (CLL4).

    Recommendation ID TA216/1 Question Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil

    Research recommendation
    Published
    9 June 2015

  15. How often should people with diabetic foot problems (foot ulcers, soft tissue infections, osteomyelitis or gangrene) be reviewed?

    Recommendation ID NG19/8 Question How often should people with diabetic foot problems (foot ulcers, soft tissue infections, osteomyelitis

    Research recommendation
    Published
    18 November 2019