Excluded studies

Advice

Study reference	Reason for exclusion
Blasco P A, and Stansbury J C (1996) Glycopyrrolate treatment of chronic drooling. Archives of Pediatrics & Adolescent Medicine 150: 932–5.	Study not prioritised (not the best available evidence – open-label study without a comparator)
Davidson J, Wang C, Neiman R, and Cavanaugh P (2011) A Phase-3 multicenter, open-label study assessing the safety of glycopyrrolate oral solution for the management of pathologic drooling in pediatric patients with cerebral palsy or other neurologic conditions. Annals of Neurology 70: S171.	Abstract only – results of this study discussed in Zeller et al. 2012b
Evatt M L (2011) Oral glycopyrrolate for the treatment of chronic severe drooling caused by neurological disorders in children. Neuropsychiatric Disease & Treatment 7: 543–7.	Not a relevant study
Montgomery J, McCusker S, Lang K, Grosse S, Mace A, Lumley R, and Kubba H (2016) Managing children with sialorrhoea (drooling): Experience from the first 301 children in our saliva control clinic. International Journal of Pediatric Otorhinolaryngology 85: 33–9.	Study not prioritised (not the best available evidence – clinician survey)
Parr J R, Buswell C A, Banerjee K, Fairhurst C, Williams J, O'Hare A, Pennington L, British Academy of Childhood Disability Drooling Study Development, and Group (2012) Management of drooling in children: a survey of UK paediatricians' clinical practice. Child: Care, and Health & Development, 38: 287-91.	Study not prioritised (not the best available evidence – clinician survey)
Parr J R, Todhunter E, Pennington L, Cole M, Morrison J, Stocken D, and Colver A. (2016) The drooling reduction intervention (DRI) trial: Is hyoscine or glycopyrronium more effective and acceptable for the treatment of drooling in children with neurodisability?. Archives of Disease in Childhood 101: A55-A56.	Abstract only
Stern L M. (1997) Preliminary study of glycopyrrolate in the management of drooling. Journal of Paediatrics & Child Health 33: 52–4.	Study not prioritised (not the best available evidence – preliminary study using parent/carer questionnaires)
Walshe M, Smith M, Pennington L (2012) Interventions for drooling in children with cerebral palsy. Cochrane Database of Systematic Reviews issue 11. Art. No.: CD008624. DOI: 10.1002/14651858.CD008624.pub3	Study not prioritised (not the best available evidence – meta‑analysis that did not include key studies)