Advice

Appendix: Search strategy and evidence selection

Appendix: Search strategy and evidence selection

Search strategy

General background, guidelines and technology assessments:

  1. NICE Evidence

  2. NICE

  3. Euroscan

  4. Broad internet search: Google e.g.: allintext: stasis or transit or motility or dysmotility or prokinetic or emptying domperidone OR motilium "children" filetype:pdf

  5. Scirus

MEDLINE & Embase (via Ovid)

  1. Domperidone/ (1500)

  2. (domperidon$ or gastrocure or r33812 or peridys or nauzelin or domidon or motilium).tw. (1920)

  3. or 2 (2216)

  4. exp INFANT/ (898300)

  5. infant?.tw. (264474)

  6. (newborn$ or neonate$).tw. (169408)

  7. (baby or babies).tw. (49222)

  8. exp Child/ (1477675)

  9. (child? or children?).tw. (833828)

  10. ADOLESCENT/ (1528060)

  11. (adolescen$ or teenager$).tw. (165106)

  12. p?ediatric$.tw. (201790)

  13. or/4-12 (3016395)

  14. and 13 (250)

  15. exp Feeding Methods/ (35982)

  16. Intubation, Gastrointestinal/ (8055)

  17. ((oral or orally or sip or bottle) adj2 (feed$ or nutrition$ or nourish$)).tw. (5213)

  18. ((enteral or enteric) adj2 (nutrition$ or feed$)).tw. (9280)

  19. Duodenostomy/ or Gastrostomy/ or Jejunostomy/ (7854)

  20. (gastrostom$ or jejunostom$ or gastrojejunostom$).tw. (9477)

  21. ((duoden$ or gastro$ or gastric or nas??gastric or nas??-gastric or nas??jejun$ or nas??duoden$ or nas??-duoden$ or jejun$ or tube?) adj2 (nutrition$ or feed$)).tw. (7917)

  22. ((PEG or NG) adj tube?).tw. (770)

  23. exp Intensive care/ (18247)

  24. (intensive care or ICU).tw. (91420)

  25. exp Gastrointestinal motility/ (31800)

  26. ((gastr$ or intestin$ or gut) adj3 (motil$ or dysmotil$ or stimulat$ or emptying or transit)).tw. (27315)

  27. peristalsis.tw. (3489)

  28. prokinetic?.tw. (1815)

  29. or/15-28 (201338)

  30. 14 and 29 (58)

  31. limit 30 to english language (43)

Cochrane Central Register of Controlled Trials (CENTRAL)

#1 MeSH descriptor: [Domperidone] explode all trees 174

#2 (domperidon* or gastrocure or r33812 or peridys or nauzelin or domidon or motilium):ti,ab,kw (Word variations have been searched) 400

#3 MeSH descriptor: [Feeding Methods] explode all trees 2754

#4 MeSH descriptor: [Intubation, Gastrointestinal] explode all trees 532

#5 (oral feed* or tube feed* or enteral or enteric):ti,ab,kw (Word variations have been searched) 5564

#6 (gastrostom* or jejunostom* or gastrojejunostom*):ti,ab,kw (Word variations have been searched) 440

#7 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2341

#8 (gastro* motility or gastr* emptying or dysmotility or peristalsis or gastr* transit):ti,ab,kw (Word variations have been searched) 3881

#9 #1 or #2 400

#10 #3 or #4 or #5 or #6 or #7 or #8 10902

#11 #9 and #10 in Trials 88

CRD HTA, DARE and EED database

  1. (domperidone) OR (motilium) 25

  2. MeSH DESCRIPTOR Feeding Behavior EXPLODE ALL TREES 201

  3. MeSH DESCRIPTOR Enteral Nutrition EXPLODE ALL TREES 161

  4. MeSH DESCRIPTOR Intubation, Gastrointestinal EXPLODE ALL TREES 36

  5. (enteral) OR (enteric) OR (feed) OR (nasogastric) OR (gastrostom*) 475

  6. MeSH DESCRIPTOR Gastrointestinal Motility EXPLODE ALL TREES 37

  7. (motility) OR (dysmotility) OR (emptying) OR (prokinetic*) OR (peristalsis) 169

  8. #2 OR #3 OR #4 OR #5 OR #6 OR #7829

  9. #1 AND #8 12

Grey literature and ongoing trials

  1. FDA

  2. EMA

  3. MHRA

  4. Scottish Medicines Consortium

  5. All Wales Medicine Strategy Group

  6. metaRegister of Controlled Trials (mRCT)

  7. ClinicalTrials.gov

Manufacturers' websites

McNeil Products UK

Zentiva

Evidence selection

The literature search looked for published evidence that investigated using domperidone in children and young people (under 18 years old) being enterally fed to promote tolerance of enteral feeds. No restrictions on study type or publication date were used in the initial search.

Studies in adults, those specifying non-enteral feeding methods, and those without an abstract to review, were excluded. Studies that, from the title and abstract, described using domperidone to treat specific conditions such as dyspepsia, diabetic gastroparesis or gastro-oesophageal reflux disease without reference to enteral feeding or improving feeding tolerance were also excluded from full text review.

This selection process found 1 partially blinded, randomised crossover study relevant to the off-label indication and population of interest. A retrospective look through the initial search results was undertaken to identify any additional relevant case reports, but none was found. Therefore, the single study provided the main evidence for this summary.