Polycystic ovary syndrome: metformin in women not planning pregnancy

(metformin or glucophage or dimethylbiguanidine or dimethylguanylguanidine or metsol).tw.

Metformin/

1 or 2

Polycystic Ovary Syndrome/

(pcos or (polycystic adj ovar*) or (sclerocystic adj ovar*) or (Stein-Leventhal adj syndrome)).tw.

4 or 5

3 and 6

exp review/

(scisearch or psychinfo or psycinfo or medlars or embase or psychlit or psyclit or cinahl or pubmed or medline).ti,ab,sh.

((hand adj2 search$) or (manual$ adj2 search$)).ti,ab,sh.

((electronic or bibliographic or computeri?ed or online) adj4 database$).ti,ab.

(pooling or pooled or mantel haenszel).ti,ab,sh.

(peto or dersimonian or der simonian or fixed effect).ti,ab,sh.

or/9-13

8 and 14

Meta Analysis/

(meta-analys$ or meta analys$ or metaanalys$).ti,ab,sh.

((systematic$ or quantitativ$ or methodologic$) adj5 (review$ or overview$ or synthesis$)).ti,ab,sh.

(integrative research review$ or research integration).ti,ab,sh.

or/16-19

15 or 20

clinical trials, phase iv/ or clinical trials, phase iii/ or randomized controlled trials/ or multicenter studies/

(random$ or placebo$ or ((singl$ or double$ or triple$ or treble$) and (blind$ or mask$))).ti,ab,sh.

22 or 23

(animal$ not human$).sh.

24 not 25

(economic? or cost?).tw.

21 or 26

7 and 28

7 and 27

29 or 30

limit 31 to english language

(metformin or glucophage or dimethylbiguanidine or dimethylguanylguanidine or metsol)

MeSH DESCRIPTOR metformin EXPLODE ALL TREES

MeSH DESCRIPTOR Polycystic Ovary Syndrome EXPLODE ALL TREES

((polycystic NEXT ovar*) OR (sclerocystic NEXT ovar*) OR (Stein-Leventhal NEXT Syndrome) OR pcos)

#1 OR #2

#3 OR #4

#5 AND #6

(metformin or glucophage or dimethylbiguanidine or dimethylguanylguanidine or metsol):ti,ab,kw

MeSH descriptor: [Metformin] this term only

#1 or #2

(pcos or (polycystic next ovar*) or (sclerocystic next ovar*) or (Stein-Leventhal next syndrome)):ti,ab,kw

MeSH descriptor: [Polycystic Ovary Syndrome] this term only

#4 or #5

#3 and #6 in Cochrane Reviews (Reviews only) and Trials

FDA

EMA

MHRA

Scottish Medicines Consortium

All Wales Medicine Strategy Group

Manufacturers' websites as applicable

metaRegister of Controlled Trials (mRCT)

ClinicalTrials.gov