Summary
Effectiveness
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Two randomised controlled trials (n=312, n=22) showed statistically significant improvement in asthma‑related quality of life in people with severe persistent allergic asthma when Airsonett was compared with a placebo device.
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There was no statistically significant difference in asthma medication usage or exacerbation rates, which were secondary outcome measures in 1 randomised controlled trial.
Adverse events and safety
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The device is non‑invasive and non‑pharmaceutical.
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No treatment‑related adverse events were identified.
Cost and resource use
The Airsonett device would be added to existing treatment and the average cost of long‑term treatment is £5.72 per day. The estimated cost of an add‑on therapy currently used in NHS practice, omalizumab, is £23 per day.
Technical factors
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The device is used in the home to deliver cooled and filtered laminar airflow around the user's breathing zone (their nose and mouth). It is powered by domestic mains electricity.
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The manufacturer provides both maintenance and consumables for the device.