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    PLGF-based testing to help diagnose suspected preterm pre-eclampsia (update of DG23)

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    4 Recommendations for further research

    4.1 A high quality test accuracy study is needed for the BRAHMS sFlt-1 Kryptor/BRAHMS PLGF plus Kryptor PE ratio test, using thresholds defined by the company and with the test used as intended in the NHS.

    4.2 Further research is recommended on repeat PLGF (placental growth factor)‑based testing, with standard clinical assessment, in women presenting with suspected pre‑eclampsia, who have had a negative PLGF‑based test result that was used to rule out pre‑eclampsia (see section 3.7). This should include:

    • exploring the different scenarios in which repeat testing may be indicated

    • the appropriate intervals between PLGF‑based tests

    • the diagnostic accuracy of PLGF‑based testing in women with suspected pre‑eclampsia who have previously had 1 or more negative PLGF‑based test results.

    4.3 Further research is recommended into how the well the tests work when women are pregnant with more than 1 baby to find out if different cut-offs are needed (see section 3.15).