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    Appendix

    The following table outlines the studies that are considered potentially relevant to the IP overview but were not included in the summary of the key evidence. It is by no means an exhaustive list of potentially relevant studies.

    Additional papers identified

    Article

    Number of patients/ followup

    Direction of conclusions

    Reasons for non-inclusion in summary of key evidence section

    Houlind K (2020) Surgical revascularization and reconstruction procedures in diabetic foot ulceration. Diabetes/metabolism research and reviews 36(S1): e3256

    Review

    Open surgical techniques in addition to more routinely performed procedures such as thrombendartecectomies and bypass to femoropopliteal or crural vessels, have acceptable results by increasing limb salvage rates in patients for whom amputation would otherwise have been the only option. These techniques are probably

    underutilized in many centres. Most of them do not require much extra in terms of facilities or instruments and they should be incorporated into routine practice in centres which manage patients with complex diabetic foot pathology.

    Review article

    Lichtenberg M, Schreve MA, Ferraresi R et al. (2018) Surgical and endovascular venous arterialization for treatment of critical limb ischaemia. VASA. Zeitschrift fur Gefasskrankheiten 47(1): 17-22

    Review

    Chronic CLI continues to be a challenge. Venous arterialisation may be a viable alternative for the preservation of limbs but the technique is not fully developed yet. Forward pressure seems to be a key factor. The percutaneous approach helps to reduce surgical stress in this vulnerable patient group.

    Review article

    Lu XW, Idu MM, Ubbink DT et al. (2006) Meta-analysis of the clinical effectiveness of venous arterialization for salvage of critically ischaemic limbs. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 31(5): 493-9

    Meta-analysis

    n=228 (7 studies)

    On the basis of limited evidence, venous arterialisation may be considered as a viable alternative before major amputation is undertaken in patients with 'inoperable' chronic critical leg ischaemia.

    Outcomes for this procedure were not reported separately and the relevant article (English language) was included in the key evidence.

    Schreve MA, Vos CG, Vahl AC et al. (2017) Venous arterialisation for salvage of critically ischaemic limbs: a systematic review and meta-analysis. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 53(3): 387-402

    Systematic review and meta-analysis

    n=768 (15 studies)

    In this systematic review on venous arterialisation in patients with non-reconstructable CLI, the pooled proportion of limb salvage at 12 months was 75%. Venous arterialisation could be a valuable treatment option in patients facing amputation of the affected limb; however, the current evidence is of low quality.

    Outcomes for this procedure were not reported separately and 4 studies that were relevant to this procedure were included in the key evidence.

    Schreve MA, Unlu C, Kum S et al. (2017) Surgical and endovascular venous arterialization: ready to take the "desert" by storm? The Journal of cardiovascular surgery 58(3): 402-8

    Review

    Venous arterialisation may be a viable alternative to preserving limbs. The percutaneous approach shows promise and is a minimally invasive technique to reduce surgical stress in patients with CLI.

    Review article

    Sheil AGR (1977) Treatment of critical ischaemia of the lower limb by venous arterialisation: an interim report. British journal of surgery 64(3): 197-9

    Case series

    n=6

    Although as a result of the procedure amputation was avoided in 3 out of 6 patients, the place of the method in the treatment of critical ischaemia of the lower limb remains dubious. Further investigation and modification of the method are planned.

    Small sample