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    The content on this page is not current guidance and is only for the purposes of the consultation process.

    Interventional procedure overview of tunnelled peritoneal drainage catheter insertion of refractory ascites in cirrhosis

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    Additional information considered by IPAC

    Professional experts' opinions

    Expert advice was sought from consultants who have been nominated or ratified by their professional Society or Royal College. The advice received is their individual opinion and is not intended to represent the view of the society. The advice provided by professional experts, in the form of the completed questionnaires, is normally published in full on the NICE website during public consultation, except in circumstances but not limited to, where comments are considered voluminous, or publication would be unlawful or inappropriate. 3 professional expert questionnaires for long term tunnelled peritoneal drainage catheter insertion for palliation of refractory ascites in cirrhosis were submitted and can be found on the NICE website.

    Patient commentators' opinions

    NICE's Public Involvement Programme will send questionnaires to NHS trusts for distribution to patients who had the procedure (or their carers). When NICE has received the completed questionnaires, these will be discussed by the committee.

    Company engagement

    A structured information request was sent to 6 companies who manufacture a potentially relevant device for use in this procedure. NICE received 2 completed submissions. These was considered by the IP team and any relevant points have been taken into consideration when preparing this overview.

    Issues for consideration by IPAC

    • long term ascitic drains (LTAD) also being used in patients with refractory malignant ascites is out of the scope of this review.

    • Studies where indwelling catheters were inserted for a short period (2-5 days) were not included in the overview.

    Ongoing studies

    NIHR133889: Palliative long-term abdominal drains versus repeated drainage in untreatable ascites due to advanced cirrhosis: a randomised controlled trial (REDUCe 2 Study). Location University of Sussex UK (study funded by NIHR HTA)

    NCT04569565: Prospective evaluation of PleurX drain for treatment of cirrhotic refractory ascites; interventional study, single group assignment, n=12; indication: cirrhotic refractory or resistant ascites; device used: PleurX catheter; primary outcome: ascites symptom inventory score (ASI-7) [change from baseline to 6 months; study completion date: March 2019; location: Canada; status: completed.

    NCT02975726: Peritoneal dialysis catheters for the treatment of refractory ascites management: a randomized un-blinded pilot study; n=2, peritoneal dialysis catheter versus LVP; primary outcome: change in the physical component of QOL 2 months post intervention; location Canada; study completion date: February 2019; status: completed.