Interventional procedure overview of removal, preservation and reimplantation of ovarian tissue to restore fertility after gonadotoxic treatment
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Methods
NICE identified studies and reviews relevant to removal, preservation and reimplantation of ovarian tissue to restore fertility from the medical literature. The following databases were searched between the date they started to 8 November 2022: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The following inclusion criteria were applied to the abstracts identified by the literature search.
Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that not available in the published literature.
Patients who had OTC for fertility preservation.
Intervention or test: OTT to restore fertility.
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.
Find out more about how NICE selects the evidence for the committee.
Databases | Date searched | Version/files |
MEDLINE (Ovid) | 08/11/2022 | 1946 to November 07, 2022 |
MEDLINE In-Process (Ovid) | 08/11/2022 | 1946 to November 07, 2022 |
MEDLINE Epubs ahead of print (Ovid) | 08/11/2022 | 1946 to November 07, 2022 |
EMBASE (Ovid) | 08/11/2022 | 1974 to 2022 November 07 |
EMBASE Conference (Ovid) | 08/11/2022 | 1974 to 2022 November 07 |
Cochrane Database of Systematic Reviews – CDSR (Cochrane Library) | 08/11/2022 | Issue 11 of 12, November 2022 |
Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library) | 08/11/2022 | Issue 10 of 12, October 2022 |
International HTA database (INAHTA) | 08/11/2022 | - |
Trial sources searched April 2022
Clinicaltrials.gov
ISRCTN
WHO International Clinical Trials Registry
Websites searched
National Institute for Health and Care Excellence (NICE)
NHS England
Food and Drug Administration (FDA) - MAUDE database
Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP – S)
Australia and New Zealand Horizon Scanning Network (ANZHSN)
General internet search
The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.
2 Tissue Preservation/
3 Tissue Transplantation/ or Transplants/
4 or/1-3
5 Ovary/
6 Ovary/tr [Transplantation]
7 Ovary.tw.
8 or/5-7
9 4 and 8
10 (ovar* adj4 tissue* adj4 (transplant* or graft* or preserv* or reimplant* or re-implant* or freez* or frozen or cryopreserv* or cryofixat* or "cryonic suspen*")).tw.
11 (OTC or OTT or OTCT).tw.
12 9 or 10 or 11
13 infertility/ or infertility, female/
14 infertilit*.tw.
15 Ovary/de, re [Drug Effects, Radiation Effects]
16 (subfertili* or sub-fertil*).tw.
17 (Ovar* adj4 (damage* or fail* or fertil* or infert* or subfert* or sub-fert*)).tw.
18 or/13-17
19 12 and 18
20 animals/ not humans/
21 19 not 20
22 limit 21 to english language
23 Fertility Preservation/
24 (Fertil* adj4 (preservat* or keep* or gaurd* or stor*)).tw.
25 18 or 23 or 24
26 12 and 25
27 animals/ not humans/
28 26 not 27
29 limit 28 to english language
30 29 not 22
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