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    Interventional procedure overview of endoluminal gastroplication for gastro-oesophageal reflux disease

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    In a crossover RCT of 63 people, the average regurgitation score according to the mean RDQ across regurgitation items (scored 0 to 5 with higher scores indicating greater severity) decreased from 3 on PPI and 3.7 off PPI at baseline to 0.6 at 1 year (n=60; p<0.001), 0.6 at 3 years (n=52; p<0.001), and 0.7 at 5 years (n=44; p<0.001). Elimination of troublesome regurgitation (according to the RDQ) was 88% (n=48) at 1 year, 90% (n=41) at 3 years and 86% (95% CI 72 to 94%, n=43) at 5-year follow up (Trad 2018).

    In an RCT of 70 people, the median percentage improvement in regurgitation score according to GORD-HRQL in people assigned to EFTP was 60% (IQR 48% to 92%) after 3 months, 96% (IQR 60% to 100%) after 6 months and 100% (IQR 90% to 100%) after 12 months. These median improvement endpoints were all statistically significant compared with sham treatment (p=0.001; Kalapala 2022).