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    In the crossover RCT of 63 people, the average RSI score (scored 0 to 45 with higher scores indicating greater severity) decreased from 22.2 on PPI and 26 off PPI at baseline to 6.3 at 1 year (n=60; p<0.001), 4.3 at 3 years (n=52; p<0.001), and 6.8 at 5-year follow up (n=44; p<0.001). Elimination of troublesome atypical symptoms according to RSI was 82% (95% CI 70 to 90%, n=55) at 1 year, 82% (95% CI 75 to 95%, n=48) at 3 years and 80% (95% CI 64 to 89%, n=39) at 5-year follow up (Trad 2018).

    In a case series of 46 people, the median RSI score at baseline in those completing 3-year follow up was 23.5 (95% CI 17 to 25.5) and decreased to 6 (95% CI 2.3 to 15, p=0.01) after 3 years. The proportion of people who had at least a 50% reduction in symptom score according to RSI in intention to treat (ITT) analysis was 70% (32/46) at 6 months, 70% (32/46) at 1 year, 62% (24/39) at 2 years and 60% (21/35) at 3 years (Testoni 2022).

    Quality of life