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    Methods

    NICE identified studies and reviews relevant to middle meningeal artery embolisation for CSDH from the medical literature. The following databases were searched between the date they started to 11 May 2022: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.

    The following inclusion criteria were applied to the abstracts identified by the literature search.

    • Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that not available in the published literature.

    • Patients: adult patients with CSDH.

    • Intervention or test: MMAE as upfront/primary, prophylactic/adjunct, or rescue treatment.

    • Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.

    If selection criteria could not be determined from the abstracts the full paper was retrieved.

    Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.

    Find out more about how NICE selects the evidence for the committee.

    Table 4 literature search strategy

    Databases

    Date searched

    Version/files

    MEDLINE (Ovid)

    12/05/2022

    1946 to May 11, 2022

    MEDLINE In-Process (Ovid)

    12/05/2022

    1946 to May 11, 2022

    MEDLINE Epubs ahead of print (Ovid)

    12/05/2022

    May 11, 2022

    EMBASE (Ovid)

    12/05/2022

    1974 to May 11, 2022

    EMBASE Conference (Ovid)

    12/05/2022

    1974 to May 11, 2022

    Cochrane Database of Systematic Reviews – CDSR (Cochrane Library)

    12/05/2022

    Issue 5 of 12, May 2022

    Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library)

    12/05/2022

    Issue 4 of 12, April 2022

    International HTA database (INAHTA)

    12/05/2022

    -

    Trial sources searched

    • Clinicaltrials.gov

    • ISRCTN

    • WHO International Clinical Trials Registry

    Websites searched

    • National Institute for Health and Care Excellence (NICE)

    • NHS England

    • Food and Drug Administration (FDA) - MAUDE database

    • Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP – S)

    • Australia and New Zealand Horizon Scanning Network (ANZHSN)

    • General internet search

    The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.

    MEDLINE search strategy

    1 Meningeal Arteries/        

    2        (middle adj4 meningeal adj4 arter*).tw.        

    3        MMA.tw.       

    4        or/1-3        

    5        Embolization, Therapeutic/        

    6        Endovascular Procedures/        

    7        (Emboli* or endovascular).tw.        

    8        or/5-7        

    9        4 and 8        

    10        exp Intracranial Hemorrhages/        

    11        ((Intracranial or subdural or brain or Posterior Fossa) adj4 (h?ematoma* or h?emorrhag*)).tw.        

    12        craniocerebral trauma/ or head injuries, closed/ or head injuries, penetrating/        

    13        ((head or skull or cranio*) adj4 (injur* or trauma)).tw.        

    14        CSDH.tw.        

    15        or/10-14        

    16        9 and 15        

    17        (ONYX* adj4 ((liquid adj4 embolic adj4 system) or LES or Medtronic)).tw.        

    18        15 and 17        

    19        16 or 18        

    20        Animals/ not Humans/        

    21        19 not 20