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    Literature search strategy

    Databases

    Date searched

    Version/files

    MEDLINE (Ovid)

    04/05/2022

    1946 to May 03, 2022

    MEDLINE In-Process (Ovid)

    04/05/2022

    1946 to May 03, 2022

    MEDLINE Epubs ahead of print (Ovid)

    04/05/2022

    May 03, 2022

    EMBASE (Ovid)

    04/05/2022

    1974 to 2022 May 03

    Cochrane Database of Systematic Reviews – CDSR (Cochrane Library)

    04/05/2022

    Issue 4 of 12, April 2022

    Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library)

    04/05/2022

    Issue 4 of 12, April 2022

    International HTA database (INAHTA)

    04/05/2022

    -

    The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.

    MEDLINE search strategy

    Number

    Search term

    1

    exp Prostatic Neoplasms/

    2

    (prostat* adj4 (neoplas* or cancer* or carcinoma* or adenocarcinom* or tumour* or tumor* or malignan* or metasta* or angiosarcoma* or chrondosarcoma* or sarcoma* or teratoma* or lymphoma* or blastoma* or microcytic* or carcinogenes* or leiomyosarcoma* or lump*)).tw.

    3

    1 or 2

    4

    Hydrogels/

    5

    Hydrogel, Polyethylene Glycol Dimethacrylate/

    6

    (hydrogel* or hydrodissect*).tw.

    7

    (spacer* or spacing).tw.

    8

    ((perirect* or rect* or prostate-rectum or denonvillier* or transperineal*) adj4 space*).tw.

    9

    or/4-8

    10

    3 and 9

    11

    spaceOAR*.tw.

    12

    Augmenix*.tw.

    13

    11 or 12

    14

    10 or 13

    15

    animals/ not humans/

    16

    14 not 15

    17

    limit 16 to ed=20200622--20220504

    18

    limit 17 to english language