Interventional procedure overview of phrenic nerve pacing for ventilator-dependent high cervical spinal cord injury
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Methods
NICE identified studies and reviews relevant to phrenic nerve pacing (PNP) for ventilator-dependent high cervical spinal cord injury (SCI)SCI from the medical literature. The following databases were searched between the date they started to 11 October 2013: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The following inclusion criteria were applied to the abstracts identified by the literature search.
Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events not available in the published literature.
People with high cervical SCI with ventilator dependency.
Intervention or test: PNP.
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.
Find out more about how NICE selects the evidence for the committee.
Databases | Date searched | Version/files |
|---|---|---|
MEDLINE ALL (Ovid) | 11/10/2023 | 1946 to October 10, 2023 |
EMBASE (Ovid) | 11/10/2023 | 1974 to 2023 October 10 |
Cochrane Database of Systematic Reviews – CDSR (Cochrane Library) | 11/10/2023 | Issue 10 of 12, October 2023 |
Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library) | 11/10/2023 | Issue 10 of 12, October 2023 |
International HTA database (INAHTA) | 11/10/2023 | - |
Trial sources searched:
Clinicaltrials.gov
ISRCTN
WHO International Clinical Trials Registry.
Websites searched:
National Institute for Health and Care Excellence (NICE)
NHS England
Food and Drug Administration (FDA) - MAUDE database
Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP – S)
Australia and New Zealand Horizon Scanning Network (ANZHSN)
General internet search.
The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.
1 Phrenic Nerve/
2 Diaphragm/
3 1 or 2
4 (pacing or stimulat*).tw.
5 3 and 4
6 ((phrenic nerve* or diaphragm*) adj4 (pacing or stimulat*)).tw.
7 5 or 6
8 ((Congenital adj2 central adj2 hypoventilation adj2 syndrome*) or CCHS).tw.
9 (Primary adj2 central adj2 hypoventilation adj2 syndrome*).tw.
10 (Central adj4 hypoventilation).tw.
11 "Ondine's curse".tw.
12 or/8-11
13 Spinal Cord Injuries/
14 ((Spinal adj4 cord adj4 (injur* or trauma* or contusion* or lacerat*)) or SCI).tw.
15 Respiration, Artificial/
16 (((artificial or mechanical) adj4 ventilat*) or (Ventilat* adj4 dependen*)).tw.
17 Respiratory Insufficiency/
18 (Respiratory adj4 (failure* or artificial or Insufficien* or depression)).tw.
19 or/13-18
20 12 or 19
21 7 and 20
22 (Avery adj4 Diaphragm adj4 (Pace* or pacing)).tw.
23 ((Atrostim or atrotech) adj4 (Phrenic adj4 Nerve)).tw.
24 21 or 22 or 23
25 Animals/ not Humans/
26 24 not 25
27 limit 26 to english language
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