Interventional procedure overview of MRI-guided focused ultrasound subthalamotomy for treating Parkinson's
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Methods
NICE identified studies and reviews relevant to MRI-guided focused ultrasound subthalamotomy from the medical literature. The following databases were searched between the date they started to 03-04-2024: MEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The following inclusion criteria were applied to the abstracts identified by the literature search:
Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that are not available in the published literature.
Patients with Parkinson's disease.
Intervention or test: MRI-guided focused ultrasound for subthalamotomy.
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.
Find out more about how NICE selects the evidence for the committee.
Databases | Date searched | Version/files |
MEDLINE ALL (Ovid) | 03/04/2024 | 1946 to April 02, 2024 |
EMBASE (Ovid) | 03/04/2024 | 1974 to 2024 April 02 |
EMBASE Conference (Ovid) | 03/04/2024 | 1974 to 2024 April 02 |
Cochrane Database of Systematic Reviews – CDSR (Cochrane Library) | 03/04/2024 | Issue 3 of 12, March 2024 |
Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library) | 03/04/2024 | Issue 3 of 12, March 2024 |
International HTA database (INAHTA) | 03/04/2024 | - |
Trial sources searched
Clinicaltrials.gov
ISRCTN
WHO International Clinical Trials Registry
Websites searched
National Institute for Health and Care Excellence (NICE)
NHS England
Food and Drug Administration (FDA) - MAUDE database
Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP – S)
Australia and New Zealand Horizon Scanning Network (ANZHSN)
General internet search
The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.
1 Parkinson Disease/ 85262
2 Parkinsonian Disorders/ 9511
3 PD.tw. 196741
4 parkinson*.tw. 149398
5 Tremor/ or Essential Tremor/ 13362
6 Tremor*.tw. 27197
7 Movement Disorders/ 17052
8 ((movement* or motor) adj4 (disord* or diseas* or dysfunct*)).tw. 58481
9 (shaking palsy or shaking palsies).tw. 83
10 (Paralysis adj4 agitans).tw. 204
11 or/1-10 360481
12 Subthalamus/ 282
13 ((Thalamic* adj4 Fasciculus) or (Field adj4 (H1 or H2) adj4 Forel*) or (Forel* adj4 Field adj4 (H1 or H2)) or (Nucleus adj4 "Field H") or (Nucleus adj4 Campi adj4 Forel*) or (Campi adj4 Forel* adj4 Nucleus) or (Forel* adj4 Nucleus adj4 Campi) or (Lenticular adj4 Fasciculus) or (Nucleus adj4 Ansa adj4 Lenticularis) or (Ansa adj4 Lenticularis adj4 Nucleus)).tw. 257
14 Subthalamic Nucleus/ 4839
15 ((Body adj4 Luys) or (Corpus adj4 Luysi) or (Nucleus adj4 Luys)).tw. 49
16 (Subthalamotom* or Subthalam*).tw. 8708
17 or/12-16 9643
18 exp Ultrasonic Therapy/ 14174
19 exp Ultrasonography, Interventional/ 32447
20 Ultrasonic Surgical Procedures/ 458
21 High-Intensity Focused Ultrasound Ablation/ 2281
22 HIFU.tw. 3053
23 ((ultraso* or ultra-so*) adj4 (unilateral or intervention*)).tw. 3192
24 (MRgFUS or MRgHIFU or FUS-STN).tw. 726
25 or/18-24 50354
26 17 and 25 42
27 ((High-intensity or focus*) adj4 subthalam*).tw. 24
28 ((ultraso* or ultra-so*) adj4 subthalam*).tw. 17
29 or/26-28 56
30 11 and 29 53
31 animals/ not humans/ 5174509
32 30 not 31 53
33 limit 32 to english language 50
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