3.1
Large B‑cell lymphoma is an aggressive type of non-Hodgkin lymphoma. There are different subtypes of large B‑cell lymphoma, including those considered within this evaluation:
diffuse large B‑cell lymphoma (DLBCL)
high-grade B‑cell lymphoma (HGBCL)
primary mediastinal B‑cell lymphoma (PMBCL)
follicular lymphoma grade 3B (FL3B).
DLBCL is the most common type. The disease characteristics and treatment pathways of each of these subtypes are considered similar at second line. People with large B‑cell lymphoma can have swollen lymph nodes, night sweats, fever, weight loss and itching. The patient expert explained that large B‑cell lymphoma has a large impact on daily life. Also, people may need the support of a carer because of physical weakness and fatigue. They also described the significant mental health challenges that people may have from:worry about the effects of the condition
the impact it has on friends and family
worry about not being able to tolerate the substantial side effects of current treatment options.
The committee recognised that relapsed or refractory large B‑cell lymphoma after first-line chemotherapy has a large disease burden.
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