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Lisocabtagene maraleucel for treating relapsed or refractory large B-cell lymphomas after first-line chemotherapy when a stem cell transplant is suitable

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2 Information about lisocabtagene maraleucel

Marketing authorisation indication

2.1

Lisocabtagene maraleucel (liso‑cel; Breyanzi, Bristol-Myers Squibb) is indicated for 'the treatment of adult patients with diffuse large B‑cell lymphoma (DLBCL), high grade B‑cell lymphoma (HGBCL), primary mediastinal large B‑cell lymphoma (PMBCL) and follicular lymphoma grade 3B (FL3B), who relapsed within 12 months from completion of, or are refractory to, first-line chemoimmunotherapy'.

Dosage in the marketing authorisation

Price

2.3

The list price for a single infusion, including shipping, engineering and generation of CAR T‑cells is £297,000, (company submission, May 2024).

2.4

The company has a commercial arrangement, which would have applied if liso-cel had been recommended.