Research recommendation(s) from an individual piece of guidance Guidance: Bipolar disorder: assessment and management Date issued: 24 September 2014 Research recommendations coming out of this guidance Maintenance treatment:- In the maintenance treatment of bipolar disorder, what is the relative effect on quality of life of lithium, an antipsychotic (haloperidol, olanzapine, quetiapine or risperidone), or a combination of lithium and an antipsychotic?