Information for the public

How is non‑Hodgkin lymphoma treated?

How is non‑Hodgkin lymphoma treated?

The following sections explain the treatments that NICE has looked at for the 6 most common types of non‑Hodgkin lymphoma. If you would like to know more about these and other treatments, see where can I find out more? and talk to your care team.

Talking to you about treatment options

There may be different ways to treat your lymphoma, and more than 1 option may be suitable for you. Your care team should explain the treatments they think will be best for you. They should tell you the pros and cons of each treatment and about any possible late effects of treatment.

They should also explain about treatments to any family members or carers who are supporting you, if you are happy with this.

At the time of publication, some medicines may be recommended for 'off-label' use in this guideline. Your doctor should tell you this and explain what it means for you.

What is 'watch and wait'?

Deciding to watch and wait for a while before starting treatment can be a good option for some people with low-grade lymphoma who are feeling well. It means that treatment is given when it can make the most difference, and side effects of treatment are avoided for longer.

Many people feel worried if a period of watch and wait is suggested. Talk to a member of your care team if you feel anxious – they should make sure you understand what is involved and why this approach is being advised.

Lymphoma that changes from low‑grade to high‑grade

Sometimes a low-grade lymphoma can start to grow more quickly and turn into a high-grade lymphoma. This is called 'transformation'. If you have a low‑grade lymphoma, a member of your care team should tell you about the possibility of transformation and explain what it means. They should also explain it to your family or carers if you are happy with this.

Transformation happens most often with follicular lymphoma and will mean you need a different type of treatment. See the section on transformed follicular lymphoma for more information.

Questions you could ask your care team

  • Which treatment do you think is best for me, and why?

  • What are the benefits of watching and waiting before starting treatment?

  • What does having this treatment involve?

  • What are the side effects of this treatment?

  • Are there any other treatments I could try?

  • Are there any long‑term effects ('late effects') of this treatment?

  • What does it mean for my outlook (prognosis) if treatment doesn't completely get rid of the lymphoma?

  • What happens if my low‑grade lymphoma transforms to a high‑grade lymphoma?

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