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Showing 4846 to 4860 of 7689 results

  1. A high-quality test accuracy study is needed for the BRAHMS sFlt‑1 Kryptor/BRAHMS PLGF plus Kryptor PE ratio test, using thresholds defined by the company, done in a population independent from that used to establish the test's thresholds, and with the test used as intended in the NHS. Further research is recommended on repeat PLGF (placental growth factor)‑based testing, with standard clinical assessment, in women presenting with suspected preterm pre-eclampsia, who have had a previous PLGF‑based test result (see section 3.7 ). This should include: - exploring the different scenarios in which repeat testing may be indicated - the appropriate intervals between PLGF‑based tests - the diagnostic accuracy of repeat PLGF‑based testing in women with suspected preterm pre-eclampsia. Further research is recommended into how well the tests work when women are pregnant with more than 1 baby to find out if different cut-offs are needed (see section 3.15 ).

    Recommendation ID DG49/01 Question A high-quality test accuracy study is needed for the BRAHMS sFlt‑1 Kryptor/BRAHMS PLGF plus Kryptor

    Research recommendation
    Published
    4 August 2022

  2. What is the minimum air exchange rate to minimise the health effects of poor indoor air quality in the home?

    Recommendation ID NG149/3 Question What is the minimum air exchange rate to minimise the health effects of poor indoor air quality in the

    Research recommendation
    Published
    10 February 2020

  3. Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung function in infants and children with cystic fibrosis?

    Recommendation ID NG78/2 Question Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung

    Research recommendation
    Published
    6 November 2018

  4. Allogeneic stem cell transplantation:- What is the effectiveness of combined autologous–allogeneic stem cell transplantation compared with autologous stem cell transplantation, plus consolidation and maintenance treatment in chemosensitive patients at first response or first relapse?

    Recommendation ID NG35/4 Question Allogeneic stem cell transplantation:- What is the effectiveness of combined autologous–allogeneic stem

    Research recommendation
    Published
    5 April 2016

  5. Additional research could help address uncertainties in the evidence, although the case for cost savings remains unlikely. Although the committee acknowledged that the Game et al. (2018) RCT was well conducted, it felt that additional research could help resolve some uncertainties around the cost and clinical case for 3C Patch. Specifically, research identifying the most appropriate stopping rule, and the associated clinical outcomes of implementing the rule, would help address key uncertainties within the cost case. Additional collection of resource use data on unhealed hard-to-heal ulcers could also reduce uncertainty in the cost case. Further to this, evidence could be collected on an UrgoStart-experienced population, as this would be reflective of current NHS care. Clinical experts thought a trial on this population would be feasible. The committee concluded that although further research could be done, on balance it was unlikely to result in a cost-saving case for 3C Patch based on the decision problem evaluated in this guidance

    Recommendation ID MTG66/01 Question Additional research could help address uncertainties in the evidence, although the case for cost savings

    Research recommendation
    Published
    8 April 2022

  6. ALT values for children and young people:- Further research should be undertaken to examine whether the upper limit of normal ALT values for adults (below 30 IU/ml for males and below 19 IU/ml for females) are appropriate for use in children and young people with chronic hepatitis B when making decisions on when to initiate treatment.

    Recommendation ID CG165/2 Question ALT values for children and young people:- Further research should be undertaken to examine whether

    Research recommendation
    Published
    9 June 2015

  7. Are environmental interventions clinically and cost effective when compared with standard care for people with psychosis and coexisting substance misuse?

    Recommendation ID CG120/7 Question Are environmental interventions clinically and cost effective when compared with standard care for people

    Research recommendation
    Published
    9 June 2015

  8. Are interventions designed to improve the quality of the mother–baby relationship in the first year after childbirth effective in women with a diagnosed mental health problem?

    Recommendation ID CG192/3 Question Are interventions designed to improve the quality of the mother–baby relationship in the first year

    Research recommendation
    Published
    9 June 2015

  9. Are interventions for psychosis or substance misuse clinically and cost effective when compared with standard care for people with psychosis and coexisting substance misuse?

    Recommendation ID CG120/5 Question Are interventions for psychosis or substance misuse clinically and cost effective when compared with

    Research recommendation
    Published
    9 June 2015

  10. Are interventions for psychosis or substance misuse clinically and cost effective when compared with standard care for people with psychosis and coexisting substance misuse?

    Recommendation ID CG120/8 Question Are interventions for psychosis or substance misuse clinically and cost effective when compared with

    Research recommendation
    Published
    9 June 2015

  11. E-cigarettes for harm reduction: Are nicotine-containing e‑cigarettes effective and safe for harm reduction when used alongside tobacco products to cut down on smoking (dual-use approach)?

    Recommendation ID NG209/06 Question E-cigarettes for harm reduction: Are nicotine-containing e‑cigarettes effective and safe for harm reduction

    Research recommendation
    Published
    17 December 2021

  12. Nicotine replacement therapy and e-cigarettes and pregnancy: Are nicotine replacement therapy or nicotine-containing e-cigarettes effective to help women stop smoking in pregnancy (and at what dose)?

    Recommendation ID NG209/02 Question Nicotine replacement therapy and e-cigarettes and pregnancy: Are nicotine replacement therapy or...

    Research recommendation
    Published
    17 December 2021

  13. Opt-out strategies for front-line health and social care staff:- Are opt-out strategies effective and cost effective at increasing uptake of flu vaccination among front-line health and social care staff?

    Recommendation ID NG103/4 Question Opt-out strategies for front-line health and social care staff:- Are opt-out strategies effective and

    Research recommendation
    Published
    12 December 2018

  14. Relapse prevention: Are NRT or nicotine-containing e‑cigarettes effective for preventing relapse after a successful quit attempt?

    Recommendation ID NG209/11 Question Relapse prevention: Are NRT or nicotine-containing e‑cigarettes effective for preventing relapse after

    Research recommendation
    Published
    17 December 2021

  15. Second-generation endometrial ablation for HMB associated with myometrial pathology:- Are outcomes after second-generation endometrial ablation for women with HMB associated with myometrial pathology (adenomyosis and/or uterine fibroids) equivalent to those for women without myometrial pathology?

    Recommendation ID NG88/5 Question Second-generation endometrial ablation for HMB associated with myometrial pathology:- Are outcomes after

    Research recommendation
    Published
    14 November 2018