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Individual research recommendation details

Recommendation details

Recommendation ID: CG149/5
Question: Duration of antibiotic treatment:- What is the optimal duration of treatment (course length) in babies who receive antibiotics for confirmed early-onset neonatal infection?
Page: 32
Any explanatory
notes (if applicable):
Why this is important:- The Guideline Development Group identified no evidence to inform the choice of duration of antibiotic treatment (course length) for confirmed early-onset neonatal infection. In the absence of evidence, the Guideline Development Group based its recommendations on its knowledge of current clinical practice. Further research is needed to evaluate different course lengths in the following clinical circumstances: - babies with group B streptococcal bacterial meningitis - babies with group B streptococcal septicaemia - babies with Gram-negative bacterial meningitis (such as Escherichia coli meningitis) - babies with Gram-negative septicaemia. The research should ideally take the form of multinational randomised controlled trials. The primary outcome should be relapse within 10 days of stopping treatment. Secondary outcomes should include long-term neurodevelopment.

Source guidance details

Comes from guidance: Antibiotics for early-onset neonatal infection
Number: CG149
Date issued: Aug 2012

Research needed into:

Effectiveness of treatment: No
Cost of treatment: No
Implementation of treatment: No
Quality of life: No
Methods of research: No

Other details

Is this a recommendation for the use of a technology only in the context of research?: No
Is it a recommendation that suggests collection of data or the establishment of a register?: No
Recommendation priority: Unrated
Recommendation status: Research Pending
Notes: 0
Date this record updated: 05-09-2012

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This page was last updated: 20 March 2014

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Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.

Accessibility | Cymraeg | Freedom of information | Vision Impaired | Contact Us | Glossary | Data protection | Copyright | Disclaimer | Terms and conditions

Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.