Overview
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The evidence assessed
Rapid review of literature
The medical literature was searched to identify studies and reviews relevant to PEARS using mesh for people with Marfan syndrome. The following databases were searched, covering the period from their start to 15 June 2021: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the Internet were also searched. No language restriction was applied to the searches (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The inclusion criteria were applied to the abstracts identified by the literature search. Where selection criteria could not be determined from the abstracts the full paper was retrieved.
Characteristic | Criteria |
|---|---|
Publication type | Clinical studies were included. Emphasis was placed on identifying good quality studies. Abstracts were excluded where no clinical outcomes were reported, or where the paper was a review, editorial, or a laboratory or animal study. Conference abstracts were also excluded because of the difficulty of appraising study methodology, unless they reported specific adverse events that were not available in the published literature. |
Patient | Patients with Marfan syndrome. |
Intervention/test | PEARS using mesh to prevent aortic root expansion and aortic dissection |
Outcome | Articles were retrieved if the abstract contained information relevant to the safety and/or efficacy. |
Language | Non-English-language articles were excluded unless they were thought to add substantively to the English-language evidence base. |
List of studies included in the IP overview
This IP overview is based on about 180 patients with Marfan syndrome who had PEARS using mesh to prevent aortic root expansion and aortic dissection from 3 cohort studies, 2 non-randomised comparative studies, 2 case series and 1 case report (Van Hoof 2021; Pepper 2020; Treasure 2014; Izgi 2018; Treasure 2012; Pepper 2015; Kockova 2019; Nemec 2020).
Other studies that were considered to be relevant to the procedure but were not included in the main summary of the key evidence are listed in the appendix.
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