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    Overview

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    Validity and generalisability of the studies

    • There are no randomised controlled trials.

    • The studies include data from the UK.

    • The studies include the first patients to have the procedure.

    • There is significant patient overlap between the studies.

    • Some studies include patients with indications other than Marfan syndrome.

    • The longest mean follow up is 6 years, but there are some results for patients with longer follow up periods.

    • A non-randomised comparative study that has only been published as an abstract has been included because it reports safety data that have not been reported elsewhere (Kockova 2019).