Interventional procedure overview of intraoperative electron beam radiotherapy for locally advanced and locally recurrent colorectal cancer
Closed for comments This consultation ended on at Request commenting lead permission
Methods
NICE identified studies and reviews relevant to intraoperative electron beam radiotherapy for locally advanced and locally recurrent colorectal cancer from the medical literature. The following databases were searched between the date they started to 29 June 2022: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The following inclusion criteria were applied to the abstracts identified by the literature search.
Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes. Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that not available in the published literature.
Patients with locally advanced or locally recurrent colorectal cancer.
Intervention or test: intraoperative electron beam radiotherapy.
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.
Find out more about how NICE selects the evidence for the committee.
Databases | Date searched | Version/files |
|---|---|---|
MEDLINE (Ovid) | 29/06/2022 | 1946 to June 28, 2022 |
MEDLINE In-Process (Ovid) | 29/06/2022 | 1946 to June 28, 2022 |
MEDLINE Epubs ahead of print (Ovid) | 29/06/2022 | June 28, 2022 |
EMBASE (Ovid) | 29/06/2022 | 1974 to 2022 June 28 |
EMBASE Conference (Ovid) | 29/06/2022 | 1974 to 2022 June 28 |
Cochrane Database of Systematic Reviews – CDSR (Cochrane Library) | 29/06/2022 | Issue 6 of 12, June 2022 |
Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library) | 29/06/2022 | Issue 6 of 12, June 2022 |
International health technology assessments database (INAHTA) | 29/06/2022 | - |
The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.
The MEDLINE search strategy was translated for use in the other sources.
1 exp Colorectal Neoplasms/
2 ((Colon* or rect* or Bowel* or colorect*) adj4 (cancer* or neoplasm* or lesion* or tumour* or tumor* or malignan* or carcinoma* or adenocarcinoma*)).tw.
3 or/1-2
4 (IOERT or IORT).tw.
5 ((Intraoperat* or intra operat or intra-operat*) adj4 radiat* therap*).tw.
6 electron beam therap*.tw.
7 ((electron* or beam*) adj4 linear adj4 accelerator*).tw.
8 or/4-7
9 3 and 8
10 Mobetron.tw.
11 LIAC.tw.
12 NOVAC.tw.
13 10 or 11 or 12
14 9 or 13
15 Animals/ not Humans/
16 14 not 15
How are you taking part in this consultation?
You will not be able to change how you comment later.
You must be signed in to answer questions