Interventional procedure overview of alcohol-mediated perivascular renal sympathetic denervation for resistant hypertension
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Appendix A: Methods and literature search strategy
NICE identified studies and reviews relevant to alcohol-mediated perivascular renal sympathetic denervation for resistant hypertension from the medical literature. The following databases were searched between the date they started to 3 May 2023: MEDLINE, PREMEDLINE, EMBASE, Cochrane Library and other databases. Trial registries and the internet were also searched (see the literature search strategy). Relevant published studies identified during consultation or resolution that are published after this date may also be considered for inclusion.
The following inclusion criteria were applied to the abstracts identified by the literature search.
Publication type: clinical studies were included with emphasis on identifying good quality studies. Abstracts were excluded if they did not report clinical outcomes (safety). Reviews, editorials, and laboratory or animal studies, were also excluded and so were conference abstracts, because of the difficulty of appraising study methodology, unless they reported specific adverse events that not available in the published literature.
Patients with (resistant) hypertension.
Intervention or test: Alcohol-mediated perivascular renal sympathetic denervation.
Outcome: articles were retrieved if the abstract contained information relevant to the safety, efficacy, or both.
If selection criteria could not be determined from the abstracts the full paper was retrieved.
Potentially relevant studies not included in the main evidence summary are listed in the section on other relevant studies.
Find out more about how NICE selects the evidence for the committee.
Databases | Date searched | Version/files |
MEDLINE (Ovid) | 03/05/2023 | 1946 to May 02, 2023 |
MEDLINE In-Process (Ovid) | 03/05/2023 | 1946 to May 02, 2023 |
MEDLINE Epubs ahead of print (Ovid) | 03/05/2023 | 1946 to May 02, 2023 |
EMBASE (Ovid) | 03/05/2023 | 1974 to 2023 May 02 |
EMBASE Conference (Ovid) | 03/05/2023 | 1974 to 2023 May 02 |
Cochrane Database of Systematic Reviews – CDSR (Cochrane Library) | 03/05/2023 | Issue 5 of 12, May 2023 |
Cochrane Central Database of Controlled Trials – CENTRAL (Cochrane Library) | 03/05/2023 | Issue 5 of 12, May 2023 |
International HTA database (INAHTA) | 03/05/2023 | - |
Trial sources searched January 2023
Clinicaltrials.gov
ISRCTN
WHO International Clinical Trials Registry
Websites searched January 2023
National Institute for Health and Care Excellence (NICE)
NHS England
Food and Drug Administration (FDA) - MAUDE database
Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP – S)
Australia and New Zealand Horizon Scanning Network (ANZHSN)
General internet search
The following search strategy was used to identify papers in MEDLINE. A similar strategy was used to identify papers in other databases.
1 exp Hypertension/
2 hypertens*.tw.
3 ((high* or raise* or elevat* or increase*) adj4 (arterial* or blood or diastolic* or systolic*) adj4 pressure*).tw.
4 (HPB or SBP or DBP or HTN).tw.
5 ((resistant* or refract* or uncontrolled*) adj4 (arterial* or blood or diastolic* or systolic*) adj4 pressure*).tw.
6 or/1-5
7 exp Sympathectomy/
8 Sympathetic Nervous System/
9 denervation/
10 catheter ablation/
11 or/7-10
12 Kidney/
13 Renal Artery/
14 (Kidney or Renal).tw.
15 or/12-14
16 11 and 15
17 ((kidney* or renal) adj4 (denervat* or sympathe* or catheter* or ablat* or neurectom* or neurotom* or perivascul*)).tw.
18 (RSD or RDN).tw.
19 or/16-18
20 6 and 19
21 Ethanol/
22 (ethyl* or ethan* or alcohol*or chemical*).tw.
23 Phenol*.tw.
24 Phenol/
25 neurolytic agent/
26 (neurolytic* adj 4 agent*).tw.
27 or/21-26
28 20 and 27
29 (Peregrine adj4 (system* or cathet*)).tw.
30 28 or 29
31 Animals/ not Humans/
32 30 not 31
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