How are you taking part in this consultation?

You will not be able to change how you comment later.

You must be signed in to answer questions

    The content on this page is not current guidance and is only for the purposes of the consultation process.

    Interventional procedure overview of alcohol-mediated perivascular renal sympathetic denervation for resistant hypertension

    Closed for comments This consultation ended on at   Request commenting lead permission

    What the procedure involves

    Before the procedure, renal artery imaging is needed to evaluate renal arterial anatomy.

    The procedure is usually done under local anaesthesia, with deep sedation and anticoagulation. A catheter is introduced through the femoral artery and advanced into each renal artery under fluoroscopic guidance. The catheter has 3 microneedles contained within 3 guide tubes. Once the catheter is positioned within the target site, the 3 tubes are simultaneously deployed against the intimal surface of the renal artery. The 3 microneedles are advanced through the renal artery wall into the adventitia and surrounding perivascular space. Microdoses of neurolytic agent (medical grade dehydrated alcohol) are then infused slowly into the perivascular space from the distal to proximal end of each renal artery. This ablates the renal nerves leading to the kidney, with the aim of disrupting neurogenic reflexes involved in blood pressure control.

    After the withdrawal of the catheter, renal artery imaging can be done to identify any adverse vascular events related to the device or the procedure.