Appendix B: Other relevant studies | Interventional procedure overview of electrically stimulated intravesical therapy for interstitial cystitis or overactive bladder in adults | Electrically stimulated intravesical therapy for interstitial cystitis or overactive bladder in adults | Consultations | NICE

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Appendix B: Other relevant studies

Other potentially relevant studies that were not included in the main evidence summary (tables 2a. 2b and 3a, 3b) are listed in table 5a and 5b below.

**Table 5a additional studies identified for interstitial cystitis**
Study	Number of people and follow up	Direction of conclusions	Reason study was not included in main evidence summary
Riedl CR, Knoll M, Plas E et al. (1997) Intravesical Electromotive Drug Administration for the Treatment of Non-Infectious Chronic Cystitis. International Urogynecology Jurnal 8: 134–137]	Cohort study n=9 Mean follow-up 11.2 months (range 3 to 22 months)	5 out of 9 (55%) had complete response, 3 (33%) had partial response, 1 had no effect.	Overlap with the Riedl (1998a) study.
Riedl CR, Knoll M, Plas E et al. (1998) Intravesical Electromotive Drug Administration Technique: Preliminary Results and Side Effects. The Journal of Urology 159:1851-1856	Cohort study n=16 Mean follow up 10.8 months (range 3 to 22 months)	The result is not separated from the chronic noninfectious cystitis (25). 15 of 25 (60%) had bladder improvement, 3 (12%) had partial response, and 7 (28%) had no improvement. No SAE reported.	13 out of 16 patient population overlap with Riedl (1998a) study

**Table 5b additional studies identified for overactive bladder**
Study	Number of people and follow up	Direction of conclusions	Reason study was not included in main evidence summary
Di Stasi S, Giannantoni A, Vespasiani G et al. (2001) Intravesical electromotive administration of oxybutynin in patients with detrusor hyperreflexia unresponsive to standard anticholinergic regimens. The Journal of Urology 165: 491–498.	n=10	No side effects reported.	No efficacy outcome reported.
Yune JJ, Shen JK, Pierce MA et al. (2018) Intravesical electrical stimulation treatment for overactive bladder: An observational study. Investigative and Clinical Urology 59:246-251	Cohort study N=17 Follow-up = 3 months	Statistically significant improvement and QOL and reduction of voiding frequency at 12 weeks. One UTI reported. No SAE reported.	Drug solution not mentioned.